GABAergic system in the endocrine pancreas: a new target for diabetes treatment
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GABAergic system in the endocrine pancreas: a new target for diabetes treatment
Excessive loss of functional pancreatic β-cell mass, mainly due to apoptosis, is a major factor in the development of hyperglycemia in both type 1 and type 2 diabetes (T1D and T2D). In T1D, β-cells are destroyed by immunological mechanisms. In T2D, while metabolic factors are known to contribute to β-cell failure and subsequent apoptosis, mounting evidence suggests that islet inflammation also ...
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ژورنال
عنوان ژورنال: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
سال: 2015
ISSN: 1178-7007
DOI: 10.2147/dmso.s50642